We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Read More
9
Magnesium nanoparticles enhance clotting time
Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
Most Useful Reviews
7.5
Blood clot prevention
112 people found this helpful
Magnesium reduces the activity of substances that contribute to blood clot formation. It is crucial for maintaining heart health and should be taken by everyone for optimal cardiovascular function.
Read More
9
Migraine solution
56 people found this helpful
After suffering from debilitating migraines for twenty years, I discovered that my magnesium deficiency was a trigger. The suggested dose for migraines is 400-800 mg daily. Following years of futile treatments, I finally found my answer. Over the past ten months, I’ve only had two headaches, which were merely stress-induced. It's crucial to take it daily for effective management, allowing it to build up in my bloodstream for sustained relief.
Read More
10
Remarkable Blood Pressure reduction
53 people found this helpful
My blood pressure has improved significantly; it used to be 160/90, now it averages at 115/65. This is fantastic!
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
Magnesium intake reduces RVO risk
Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis.
We explored whether magnesium intake could influence the risk of retinal vein occlusion (RVO), a leading cause of vision loss. Our analysis involved over 16,000 participants from a national health survey.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
Read More
8
Effective clay-based hemostatic sponge
An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen.
We examined a new sponge made from clay and collagen to control severe bleeding. Integrating palygorskite clay with collagen using gallic acid created a sponge that resists particle shedding and provides strong adhesion.
In our tests, this sponge demonstrated impressive results, reducing blood loss to 632 mg and achieving hemostasis in just 151 seconds, outperforming traditional gauze and even a well-known product called QuikClot.
With added antibacterial and antioxidant properties, this sponge could significantly enhance emergency bleeding management.
Read More
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
8
Bioresorbable stents' advancements noted
Coronary bioresorbable metallic stents: Advancements and future perspectives.
We explored the evolution of bioresorbable metallic stents as alternatives to traditional stents which can lead to complications like thrombosis and inflammation.
While bioresorbable polymeric stents face challenges, materials like zinc and magnesium show promise.
Specifically, magnesium-based stents have demonstrated successful absorption within a year and low rates of complications.
Continuing research will be essential to refine these innovations for better clinical outcomes.
Magnesium reduces the activity of substances that contribute to blood clot formation. It is crucial for maintaining heart health and should be taken by everyone for optimal cardiovascular function.
Read More
9
Migraine solution
56 people found this helpful
After suffering from debilitating migraines for twenty years, I discovered that my magnesium deficiency was a trigger. The suggested dose for migraines is 400-800 mg daily. Following years of futile treatments, I finally found my answer. Over the past ten months, I’ve only had two headaches, which were merely stress-induced. It's crucial to take it daily for effective management, allowing it to build up in my bloodstream for sustained relief.
Read More
10
Remarkable Blood Pressure reduction
53 people found this helpful
My blood pressure has improved significantly; it used to be 160/90, now it averages at 115/65. This is fantastic!
Read More
7.5
Enhanced relaxation
22 people found this helpful
This magnesium chelate supplement has been excellent for my low magnesium levels. It took three weeks for me to notice improvements. My blood pressure normalised, I feel calmer, and I sleep better at night. While I currently take 10 tablets daily to enhance magnesium intake, I expect even better results over time. It effectively alleviates headaches and migraines, although consistent dosing is essential for relief. Overall, I highly recommend it alongside a balanced vitamin/mineral supplement.
Read More
9
Natural relaxation aid
18 people found this helpful
This is the best magnesium I’ve tried compared to others, including the Now brand. It effectively aids relaxation and helps maintain my blood pressure.
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Based on user reviews, the timeline for seeing results after starting a magnesium supplement can vary, but many users report noticeable improvements within a few weeks. For instance, one user mentioned that it took about three weeks to observe significant changes, including improved blood pressure and better sleep quality (Read Review). Another reviewer reported that their husband's blood pressure normalised within a week of beginning supplementation (Read Review). It’s worth noting that consistent daily dosing is recommended to achieve the best outcomes in managing blood pressure and overall wellness (Read Review).
Moreover, users emphasize that the benefits of magnesium accrue over time with continuous use. Many experienced reductions in symptoms related to hypertension, stress, and migraines with prolonged supplementation. For example, one user stated that after years of treatments yielding little success, daily magnesium intake led to their first relief in years, further reinforcing the notion that maintaining a routine is key to seeing sustained benefits (Read Review). Therefore, while some may notice changes quickly, others may need to continue supplementation for several weeks to truly gauge the results.
The use of magnesium in relation to blood clot management shows promising potential according to multiple studies. A study indicated that bioresorbable magnesium scaffolds, like the Magmaris scaffold, exhibited significantly lower thrombogenicity compared to traditional stainless steel stents, suggesting that magnesium can enhance patient safety by reducing blood clot risks in cardiovascular treatments [3]. Furthermore, research has pointed out that a lack of magnesium transporter 1 (MAGT1) can lead to increased platelet activity and faster clotting, indicating that sufficient magnesium levels may help in preventing thrombosis [8].
In addition to cardiovascular implications, other studies have suggested that boosting magnesium levels may help address blood clotting issues in specific conditions, such as sepsis [14]. This aligns with findings that highlighted the anticoagulant effects of magnesium oxide nanoparticles, which extended clotting time in laboratory tests, paving the way for potential treatment options without adverse effects [16]. While the research indicates a beneficial relationship between magnesium and blood clot risk management, further studies are necessary to solidify these findings and fully understand the implications of magnesium supplementation in clinical settings.
Based on user reviews, many individuals report significant improvements in various symptoms related to blood pressure and migraines after starting magnesium supplementation. For instance, a user shared that their blood pressure dropped from 160/90 to a much healthier average of 115/65 (Read Review) and another noted a remarkable normalisation of blood pressure from a dangerously high 189/120 within a short period of use (Read Review, Read Review). Moreover, numerous users struggling with chronic migraines have found relief, with one reviewer claiming they experienced only two stress-induced headaches in ten months after discovering their magnesium deficiency (Read Review).
Additionally, users have highlighted the calming effects of magnesium, noting enhanced sleep quality and reduced stress levels. One reviewer remarked that consistent magnesium intake was essential for alleviating the heaviness and constriction in their chest, while another insisted on its role in improving overall health and sleep quality (Read Review). The anecdotal experiences suggest that while some notice benefits quickly, others may require continued use for effects to manifest fully, underscoring the variability in individual responses to magnesium supplementation.
Users report that combining magnesium supplements with other supplements can be beneficial for managing blood clotting and overall cardiovascular health. For example, one reviewer emphasizes that magnesium reduces the activity of substances contributing to blood clot formation, making it essential for heart health and complementing other vitamin and mineral regimens for optimal function (Read Review). Additionally, another user shares their positive experience of combining magnesium with vitamin B6, highlighting its role in alleviating stress and managing migraines, which can also tie into cardiovascular health management given the interconnected nature of these conditions (Read Review).
Moreover, multiple reviews suggest that consistent magnesium supplementation can amplify the effects of other supplements. A user mentioned that magnesium effectively complements their blood pressure management efforts alongside hawthorn, resulting in a significant improvement in their husband's blood pressure readings (Read Review). This synergy illustrates the potential for magnesium to enhance the effectiveness of a multi-supplement regime aimed at supporting cardiovascular function and overall health. With consistent use and the right combinations, users have noted substantial benefits, including lower blood pressure and improved general well-being.
Users report a variety of dosages when it comes to magnesium supplementation for managing blood pressure and overall cardiovascular health. Some users suggest taking 400-800 mg daily, especially for conditions like migraines, as this dosage allows the magnesium to build up in the bloodstream for ongoing benefits Read Review. Another user noted following a dosage of two tablets twice daily, leading to significant improvements in their blood pressure, which dropped by around 10-12 points Read Review.
Additionally, several users emphasize the importance of consistent dosing; some find effectiveness with just a couple of tablets at night to manage their blood pressure and improve sleep quality Read Review. Overall, while individual needs may vary, a daily intake spread throughout the day seems to be a common theme among those seeking to leverage magnesium for better cardiovascular function and to mitigate issues related to blood clotting and high blood pressure.
7.5
Enhanced relaxation
22 people found this helpful
This magnesium chelate supplement has been excellent for my low magnesium levels. It took three weeks for me to notice improvements. My blood pressure normalised, I feel calmer, and I sleep better at night. While I currently take 10 tablets daily to enhance magnesium intake, I expect even better results over time. It effectively alleviates headaches and migraines, although consistent dosing is essential for relief. Overall, I highly recommend it alongside a balanced vitamin/mineral supplement.
9
Beneficial during pregnancy
3 people found this helpful
This affordable magnesium was well-suited for me during pregnancy. It improved my wellbeing and alleviated discomfort. My husband started using it to combat increased blood pressure, and within a week, his pressure normalised. I plan to get more for my parents as well.
9
Natural relaxation aid
18 people found this helpful
This is the best magnesium I’ve tried compared to others, including the Now brand. It effectively aids relaxation and helps maintain my blood pressure.
9
Migraine solution
56 people found this helpful
After suffering from debilitating migraines for twenty years, I discovered that my magnesium deficiency was a trigger. The suggested dose for migraines is 400-800 mg daily. Following years of futile treatments, I finally found my answer. Over the past ten months, I’ve only had two headaches, which were merely stress-induced. It's crucial to take it daily for effective management, allowing it to build up in my bloodstream for sustained relief.
10
Remarkable Blood Pressure reduction
53 people found this helpful
My blood pressure has improved significantly; it used to be 160/90, now it averages at 115/65. This is fantastic!
9
Normal blood pressure
7 people found this helpful
I started my husband on this for his high blood pressure. He now only takes hawthorn once daily, and his blood pressure has normalised from 189/120.
7.5
Reduced heart skips
1 people found this helpful
This product has noticeably helped reduce the frequency of skipped heartbeats, which were quite distressing. It has alleviated the heaviness and constriction in my chest and has mildly lowered my borderline high blood pressure.
7.5
Blood clot prevention
112 people found this helpful
Magnesium reduces the activity of substances that contribute to blood clot formation. It is crucial for maintaining heart health and should be taken by everyone for optimal cardiovascular function.
9
Cramp relief
1 people found this helpful
Living under constant stress prompted me to take magnesium after my doctor advised it for frequent migraines. I had tried various treatments with limited success. This supplement has been a godsend, as I experience far fewer migraines now. I combine it with vitamin B6, and it doesn't cause heartburn. Magnesium supports energy production, thus reducing fatigue, particularly important for anyone in a high-stress urban environment. It aids relaxation and helps me tackle the demands of daily life better.
9
Blood pressure reduction
1 people found this helpful
Helped to take 10 points off my blood pressure. I tried this product after reading about it in the IHerb reviews. The tablets are large, but manageable with liquid. The manufacturer recommends 2 tablets twice daily. I have been using it for 2 months and got excellent results. I have a thyroid condition (hypo), and taking magnesium has reduced my blood pressure by about 10 to 12 points on average. There has been no downside thus far, and I tolerate it well. I reordered 2 larger bottles for better value. Great product at a really good price!
8
Improved sleep quality
1 people found this helpful
Wonderful, I can't do without it due to terrible insomnia and a sudden rise in blood pressure. I take two pills before bed, and it makes my sleep somewhat better. Although it’s not a sleeping pill, it helps enhance sleep quality, promoting deeper rest. Thankfully, it also controls my blood pressure, which I have noticed and greatly benefited from. If you find this evaluation helpful, please like and thank you.
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
8
MAGT1 deficiency increases thrombosis risk
MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
We studied how a lack of magnesium transporter 1 (MAGT1) impacts blood clot formation and the risk of stroke. Using various laboratory and animal models, we observed that MAGT1 deficiency leads to enhanced platelet activity and quicker clotting. This deficiency resulted in faster artery blockage and severe brain damage during strokes. Interestingly, restoring magnesium levels or blocking certain channels helped normalize platelet behavior. Overall, we found that MAGT1's function is crucial for vascular health, indicating its deficiency could elevate risks for thrombosis and ischemic stroke.
7
Magnesium affects sepsis coagulopathy
Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study.
We looked into how magnesium levels impact blood clotting during sepsis. In our study of ICU patients, we found that those with low magnesium (hypomagnesemia) showed a higher likelihood of having activated coagulation and suppressed fibrinolysis.
Notably, hypomagnesemia was linked to coagulopathy, specifically disseminated intravascular coagulation (DIC). This suggests that boosting magnesium levels could be a promising way to address blood clotting issues in septic patients.
9
Magnesium nanoparticles enhance clotting time
Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
References
Kim J, Kim M, Lee CS, Choi EY. Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis. Nutrients. 2025;17. 10.3390/nu17071285
Guo X, Zeng X, He Y, Zhang X, Shi W, et al. An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen. ACS Appl Mater Interfaces. 2025;17:16489. 10.1021/acsami.4c19209
Müller M, Ludwig L, Englert H, Riedl KA, Müller MC, et al. A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds. Sci Rep. 2024;14:26691. 10.1038/s41598-024-77266-0
Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. 10.1016/j.jjcc.2024.08.003
Włodarczak A, Rola P, Włodarczak S, Szudrowicz M, Giniewicz K, et al. Two-Year Outcomes for Patients with Non-ST-Elevation Acute Coronary Syndrome Treated with Magmaris and Absorb Bioresorbable Scaffolds in Large-Vessel Lesions. J Pers Med. 2024;14. 10.3390/jpm14050540
Galli S, Troiano S, Palloshi A, Rapetto C, Pisano F, et al. Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris Multicenter Italian Registry. Cardiovasc Revasc Med. 2023;57:53. 10.1016/j.carrev.2023.06.022
Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. 10.1177/14791641231188705
Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, et al. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arterioscler Thromb Vasc Biol. 2023;43:1494. 10.1161/ATVBAHA.122.318115
Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study. EuroIntervention. 2023;19:e414. 10.4244/EIJ-D-23-00326
Wlodarczak A, Montorsi P, Torzewski J, Bennett J, Starmer G, et al. One- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry. EuroIntervention. 2023;19:232. 10.4244/EIJ-D-22-01069
Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study. EClinicalMedicine. 2023;59:101940. 10.1016/j.eclinm.2023.101940
Pompei G, Campo G, Ruggiero R, Maffeo D, Sgura F, et al. Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: Insights from the SHERPA-MAGIC study. Int J Cardiol. 2023;383:1. 10.1016/j.ijcard.2023.04.029
Fedele G, Castiglioni S, Maier JAM, Locatelli L. The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study. Int J Mol Sci. 2023;24. 10.3390/ijms24032930
Tonai K, Katayama S, Koyama K, Sata N, Tomioka Y, et al. Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study. BMC Anesthesiol. 2022;22:359. 10.1186/s12871-022-01903-2
Seguchi M, Aytekin A, Lenz T, Nicol P, Alvarez-Covarrubias HA, et al. Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation. J Cardiol. 2023;81:179. 10.1016/j.jjcc.2022.09.003
Venkatappa MM, Udagani C, Hanumegowda SM, Pramod SN, Venkataramaiah S, et al. Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis. Molecules. 2022;27. 10.3390/molecules27165162